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I no longer recommend Beyond B12, or that anyone does business with Longevity Plus for ethical reasons, and I now Biogenesis Methyl Factors as an equivalent product for those with MTHFR genetic mutation. It's designed for those with methylation defects and who need the extra methy factors as well as preformed methytetralfolate instead of folic acid. It's designed to be 'MTHFR Safe' and is an excellent substitute for Beyond B12.
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Saccharomyces Boulardii is a specific strain of probiotic that is well studied for many reasons. Specifically, it has been studied for use against antibiotic overgrowth infections such as Clostridium Difficile, also called C-diff or antibiotic colitis that may be one of the serious side effects of the many antibiotics, including the Quinolone Antibiotics. It's so well-studied for this problem that it is often given in hospitals to treat and prevent antibiotic overgrowth infections.