Beyond B12 Methylation Factors
Biogenesis methyl factors with methylcobalamin and methylfolatebiogenesis methyl factors label

Beyond B12


I no longer  recommend Beyond B12, or that anyone does business with Longevity Plus for ethical reasons, and I now Biogenesis Methyl Factors as an equivalent product for those with MTHFR genetic mutation. It’s designed for those with methylation defects and who need the extra methy factors as well as preformed methytetralfolate instead of folic acid.  It’s designed to be ‘MTHFR Safe’ and is an excellent substitute for Beyond B12.

Out of stock

Product Description

Longevity Plus SHUT THEIR DOORS suddenly and without notice in January 2015 and I no longer recommend anyone doing business with their company for ethical reasons, as I’ve outlined here in the What Happened to Longevity Plus post.

Biogenesis Methyl Factors is as good or a better product than the Longevity Plus Beyond B12 for those with MTHFR genetic mutation. It’s designed for those with methylation defects and who need the extra methy factors in the form of methylcobalamin and methylfolate instead of  the “cheap” B12 and folic acid you’ll find in ‘regular’ supplements. There is a difference! If you do not have or suspect you have MTHFR Gene Mutation and just want a good methylcobalamin B12 product, see the Methylcobalamin B12 Supplement page for a more affordable alternative.

Methyl Factors  2 fl oz
Supplement Facts
Serving Size: 1 mL (one full squeeze of dropper)
Servings per Container: 59

Amount per Serving
Vitamin B6 2 mg
(as pyridoxal-5-phosphate)
Folate 400 mcg
(as [6S]-5-methyltetrahydrofolic acid [glucosamine salt] and
5-formyltetrahydrofolate [calcium folinate])
Vitamin B12 1,000 mcg
(as methylcobalamin)

Other Ingredients: Water, glycerin, xylitol, natural flavors, xanthan gum, citric acid, grape skin extract, sodium hexametaphosphate, potassium sorbate (to ensure freshness), sodium benzoate and stevia leaf extract.

Suggested Use: As a dietary supplement, take one serving (1 mL) one time per day or as directed by your healthcare professional.

Keep tightly capped and store in a cool, dry place. KEEP OUT OF REACH OF CHILDREN. If pregnant or breast-feeding, contact your healthcare professional before use.

Shake before use.
Refrigerate after opening.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


  1. :

    Hello— have high 99- MVC– WHEN WILL YOU GET THIS BACK IN STOCK??? Thank you

    • :

      It’s supposed to be back in stock around November 11th.

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